All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Wed 1:36 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ Cle |
| 2 | De'Von Achane | Mia vs NO |
| 3 | Bijan Robinson | Atl @ NYJ |
| 4 | Jonathan Taylor | Ind vs Hou |
| 5 | Jahmyr Gibbs | Det vs GB |
| 6 | Saquon Barkley (Q) | Phi vs Chi |
| 7 | Derrick Henry | Bal vs Cin |
| 8 | James Cook | Buf @ Pit |
| 9 | Kyren Williams | LAR @ Car |
| 10 | Josh Jacobs (Q) | GB @ Det |
| 11 | Breece Hall | NYJ vs Atl |
| 12 | TreVeyon Henderson | NE vs NYG |
| 13 | Ashton Jeanty (Q) | LV @ LAC |
| 14 | Travis Etienne | Jax @ Ten |
| 15 | Rico Dowdle | Car vs LAR |
| 16 | Chase Brown | Cin @ Bal |
| 17 | Devin Neal | NO @ Mia |
| 18 | Quinshon Judkins | Cle vs SF |
| 19 | Javonte Williams | Dal vs KC |
| 20 | Kenneth Walker III | Sea vs Min |
| Rank | Player | Match |
| 21 | RJ Harvey | Den @ Wsh |
| 22 | Woody Marks | Hou @ Ind |
| 23 | Bucky Irving (Q) | TB vs Ari |
| 24 | Jaylen Warren | Pit vs Buf |
| 25 | Tyrone Tracy Jr. | NYG @ NE |
| 26 | D'Andre Swift | Chi @ Phi |
| 27 | David Montgomery | Det vs GB |
| 28 | Zach Charbonnet | Sea vs Min |
| 29 | Aaron Jones | Min @ Sea |
| 30 | Omarion Hampton (IR) | LAC vs LV |
| 31 | Kareem Hunt | KC @ Dal |
| 32 | Tony Pollard | Ten vs Jax |
| 33 | Kenneth Gainwell | Pit vs Buf |
| 34 | Tyjae Spears | Ten vs Jax |
| 35 | Kimani Vidal | LAC vs LV |
| 36 | Bam Knight | Ari @ TB |
| 37 | Rachaad White | TB vs Ari |
| 38 | Jaleel McLaughlin | Den @ Wsh |
| 39 | Kyle Monangai | Chi @ Phi |
| 40 | Isiah Pacheco | KC @ Dal |
