All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 10:02 AM ET.
| Rank | Player | Match |
| 1 | Saquon Barkley | Phi vs Pit |
| 2 | Derrick Henry | Bal @ NYG |
| 3 | Bijan Robinson | Atl @ LV |
| 4 | Joe Mixon | Hou vs Mia |
| 5 | Chase Brown | Cin @ Ten |
| 6 | Josh Jacobs | GB @ Sea |
| 7 | De'Von Achane | Mia @ Hou |
| 8 | Chuba Hubbard | Car vs Dal |
| 9 | James Conner | Ari vs NE |
| 10 | Alvin Kamara | NO vs Wsh |
| 11 | Jahmyr Gibbs | Det vs Buf |
| 12 | Zach Charbonnet | Sea vs GB |
| 13 | Rico Dowdle | Dal @ Car |
| 14 | Tony Pollard (Q) | Ten vs Cin |
| 15 | Jonathan Taylor | Ind @ Den |
| 16 | Aaron Jones (P) | Min vs Chi |
| 17 | David Montgomery | Det vs Buf |
| 18 | Brian Robinson | Wsh @ NO |
| 19 | James Cook | Buf @ Det |
| 20 | Isiah Pacheco | KC @ Cle |
| Rank | Player | Match |
| 21 | Rachaad White | TB @ LAC |
| 22 | Rhamondre Stevenson | NE @ Ari |
| 23 | Breece Hall (Q) | NYJ @ Jax |
| 24 | D'Andre Swift (Q) | Chi @ Min |
| 25 | Tyrone Tracy Jr. | NYG vs Bal |
| 26 | Najee Harris | Pit @ Phi |
| 27 | Sincere McCormick | LV vs Atl |
| 28 | Tank Bigsby | Jax vs NYJ |
| 29 | Nick Chubb | Cle vs KC |
| 30 | Travis Etienne | Jax vs NYJ |
| 31 | Jaylen Warren | Pit @ Phi |
| 32 | Javonte Williams | Den vs Ind |
| 33 | Gus Edwards | LAC vs TB |
| 34 | Jerome Ford | Cle vs KC |
| 35 | Jaleel McLaughlin | Den vs Ind |
| 36 | Kimani Vidal | LAC vs TB |
| 37 | Braelon Allen | NYJ @ Jax |
| 38 | Bucky Irving (Q) | TB @ LAC |
| 39 | Kareem Hunt | KC @ Cle |
| 40 | Tyjae Spears | Ten vs Cin |
