All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Sat 10:42 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ NYG |
| 2 | Jonathan Taylor | Ind @ Pit |
| 3 | Jahmyr Gibbs | Det vs Min |
| 4 | Bijan Robinson | Atl @ NE |
| 5 | James Cook | Buf vs KC |
| 6 | Josh Jacobs | GB vs Car |
| 7 | Kyren Williams | LAR vs NO |
| 8 | Kyle Monangai | Chi @ Cin |
| 9 | Javonte Williams | Dal vs Ari |
| 10 | TreVeyon Henderson | NE vs Atl |
| 11 | Travis Etienne | Jax @ LV |
| 12 | Ashton Jeanty | LV vs Jax |
| 13 | Chase Brown | Cin vs Chi |
| 14 | Kimani Vidal | LAC @ Ten |
| 15 | Jaylen Warren | Pit vs Ind |
| 16 | Alvin Kamara (Q) | NO @ LAR |
| 17 | Kenneth Walker III | Sea @ Wsh |
| 18 | Tyrone Tracy Jr. | NYG vs SF |
| 19 | J.K. Dobbins | Den vs LV |
| 20 | Jacory Croskey-Merritt | Wsh vs Sea |
| Rank | Player | Match |
| 21 | Woody Marks | Hou vs Den |
| 22 | David Montgomery | Det vs Min |
| 23 | Kareem Hunt | KC @ Buf |
| 24 | Rico Dowdle | Car @ GB |
| 25 | Zach Charbonnet | Sea @ Wsh |
| 26 | Aaron Jones | Min @ Det |
| 27 | Bam Knight | Ari @ Dal |
| 28 | Tyjae Spears | Ten vs LAC |
| 29 | Tony Pollard | Ten vs LAC |
| 30 | Kenneth Gainwell | Pit vs Ind |
| 31 | Terrell Jennings | NE vs Atl |
| 32 | Jordan Mason | Min @ Det |
| 33 | Nick Chubb | Hou vs Den |
| 34 | Chuba Hubbard | Car @ GB |
| 35 | RJ Harvey | Den vs LV |
| 36 | Blake Corum | LAR vs NO |
| 37 | Brashard Smith | KC @ Buf |
| 38 | Emanuel Wilson | GB vs Car |
| 39 | Emari Demercado | Ari @ Dal |
| 40 | Tyler Allgeier | Atl @ NE |
