All position ranks are: QB RB WR TE FLEX Def
These rankings were updated as of Thu 2:55 PM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF vs NYG |
| 2 | Tony Pollard | Dal @ Ari |
| 3 | Derrick Henry (GTD) | Ten @ Cle |
| 4 | Bijan Robinson | Atl @ Det |
| 5 | Travis Etienne | Jax vs Hou |
| 6 | Josh Jacobs | LV vs Pit |
| 7 | Joe Mixon | Cin vs LAR |
| 8 | Kyren Williams | LAR @ Cin |
| 9 | Rhamondre Stevenson | NE @ NYJ |
| 10 | Jahmyr Gibbs | Det vs Atl |
| 11 | Raheem Mostert | Mia vs Den |
| 12 | Kenneth Walker III | Sea vs Car |
| 13 | Miles Sanders (GTD) | Car @ Sea |
| 14 | James Conner | Ari vs Dal |
| 15 | Brian Robinson | Wsh vs Buf |
| 16 | Rachaad White | TB vs Phi |
| 17 | D'Andre Swift | Phi @ TB |
| 18 | James Cook | Buf @ Wsh |
| 19 | Javonte Williams | Den @ Mia |
| 20 | Najee Harris | Pit @ LV |
| Rank | Player | Match |
| 21 | Zack Moss | Ind @ Bal |
| 22 | Austin Ekeler (GTD) | LAC @ Min |
| 23 | Aaron Jones (GTD) | GB vs NO |
| 24 | Isiah Pacheco (GTD) | KC vs Chi |
| 25 | Alexander Mattison | Min vs LAC |
| 26 | Dameon Pierce | Hou @ Jax |
| 27 | Jerome Ford | Cle vs Ten |
| 28 | Gus Edwards | Bal vs Ind |
| 29 | Breece Hall (GTD) | NYJ vs NE |
| 30 | Jaylen Warren | Pit @ LV |
| 31 | Tyler Allgeier | Atl @ Det |
| 32 | A.J. Dillon | GB vs NO |
| 33 | Joshua Kelley | LAC @ Min |
| 34 | Dalvin Cook | NYJ vs NE |
| 35 | Khalil Herbert | Chi @ KC |
| 36 | Roschon Johnson | Chi @ KC |
| 37 | Samaje Perine | Den @ Mia |
| 38 | Matt Breida | NYG @ SF |
| 39 | Chuba Hubbard | Car @ Sea |
| 40 | Tony Jones Jr. | Sea vs Car |
