All position ranks are: QB RB WR TE FLEX DEF
These rankings were updated as of Thu 11:19 AM ET.
| Rank | Player | Match |
| 1 | Christian McCaffrey | SF @ LAR |
| 2 | Derrick Henry | Ten vs LAC |
| 3 | Tony Pollard | Dal vs NYJ |
| 4 | Austin Ekeler (GTD) | LAC @ Ten |
| 5 | Saquon Barkley | NYG @ Ari |
| 6 | Nick Chubb | Cle @ Pit |
| 7 | Bijan Robinson | Atl vs GB |
| 8 | Josh Jacobs | LV @ Buf |
| 9 | Joe Mixon | Cin vs Bal |
| 10 | James Conner (GTD) | Ari vs NYG |
| 11 | Travis Etienne | Jax vs KC |
| 12 | David Montgomery | Det vs Sea |
| 13 | Rhamondre Stevenson | NE vs Mia |
| 14 | Kenneth Walker III | Sea @ Det |
| 15 | James Cook | Buf vs LV |
| 16 | Jahmyr Gibbs | Det vs Sea |
| 17 | Miles Sanders | Car vs NO |
| 18 | Dameon Pierce | Hou vs Ind |
| 19 | Rachaad White | TB vs Chi |
| 20 | Tyler Allgeier | Atl vs GB |
| Rank | Player | Match |
| 21 | Brian Robinson | Wsh @ Den |
| 22 | Javonte Williams | Den vs Wsh |
| 23 | Najee Harris | Pit vs Cle |
| 24 | Alexander Mattison | Min @ Phi |
| 25 | Aaron Jones (GTD) | GB @ Atl |
| 26 | Breece Hall (GTD) | NYJ @ Dal |
| 27 | Jamaal Williams | NO @ Car |
| 28 | Raheem Mostert (GTD) | Mia @ NE |
| 29 | Isiah Pacheco | KC @ Jax |
| 30 | A.J. Dillon | GB @ Atl |
| 31 | D'Andre Swift | Phi vs Min |
| 32 | Dalvin Cook | NYJ @ Dal |
| 33 | Khalil Herbert | Chi @ TB |
| 34 | Samaje Perine | Den vs Wsh |
| 35 | Kyren Williams | LAR vs SF |
| 36 | Jaylen Warren | Pit vs Cle |
| 37 | Ezekiel Elliott | NE vs Mia |
| 38 | Gus Edwards | Bal @ Cin |
| 39 | Deon Jackson | Ind @ Hou |
| 40 | Antonio Gibson | Wsh @ Den |
