These standard ranks are updated as of Nov. 24
Other Week 12 Ranks: Top 20 RBs Top 50 WRs Top 20 TEs
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| Rank | Player | Team | Opp |
| 1 | Andrew Luck | IND | MIA |
| 2 | Tom Brady | NE | @NYJ |
| 3 | Philip Rivers | LAC | AZ |
| 4 | Ben Roethlisberger | PIT | @DEN |
| 5 | Russell Wilson | SEA | @CAR |
| 6 | Aaron Rodgers | GB | @MIN |
| 7 | Deshaun Watson | HOU | TEN |
| 8 | Cam Newton | CAR | SEA |
| 9 | Kirk Cousins | MIN | GB |
| 10 | Lamar Jackson | BAL | OAK |
| 11 | James Winston | TB | SF |
| 12 | Baker Mayfield | CLE | CIN |
| 13 | Ryan Tannehill | MIA | IND |
| 14 | Carson Wentz | PHI | NYG |
| 15 | Andy Dalton | CIN | CLE |
| 16 | Nick Mullens | SF | @TB |
| 17 | Blake Bortles | JAX | @BUF |
| 18 | Eli Manning | NYG | @PHI |
| 19 | Marcus Mariota | TEN | @HOU |
| 20 | Case Keenum | DEN | PIT |
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